Endocrine Abstracts

Introduction: Growth hormone deficiency (GHD) is a medical condition affecting adults and children who lack sufficient growth hormone. The objective of this study was to compare diagnoses in acquired and idiopathic adult-onset GHD patients.Methodology: Results are from Ipsos’ EU5 GHD Therapy Monitor Study 2018, which is an online study conducted among physicians treating both paediatric and adult GHD patients. 156 sampled physicians provided d...

Introduction: Primary hypoparathyroidism (PH) is a rare condition. After surgery and chronic alcoholism, an autoimmune disease is the most common etiology and must specifically be considered in the context of a patient with other autoimmune endocrine diseases.Case report: MASD a male caucasian patient aged 31, was admitted to the emergency department because of perioral and hand paresthesias, and carpal spasm, in the context of a generalized anxiety reac...

Introduction: Therapeutic approach of patients (pts) with metastatic renal cell carcinoma (mRCC) may include the use of biological agents such as m-TOR inhibitors: temsirolimus (TM) and everolimus (EV). Its use is associated with metabolic dysfunction, especially with everolimus: hyperglycemia (37% TM treated pts vs 72% EV treated pts), hypercholesterolemia (25% TM treated pts vs 81% EV treated pts) and hypertriglyceridemia (30% TM treated pts vs 73% EV treated pts). Discontin...

Introduction: Graves’ disease is an autoimmune condition with an estimated prevalence of about 2%, 5–10 times more frequent in females. A multifactorial nature is assumed, with genetic contribution accounting for up to 80% of the variability. Relevant genes includegeneral autoimmune risk loci, such as the HLA region, CTLA-4, PTPN22 and CD40, as well as thyroid-specific loci (thyroglobulin and TSH receptor genes). We report a particular case of Graves’ d...

Introduction: Many patients with diabetes experience high variability in glucose concentrations which is associated with a risk of hypoglycemia. The aim of this was to compare the predictive value of HbA1C, mean interstitial glucose (MIG), and glucose variability (GV) in the risk of hypoglycemia in patients with type 1 diabetes (T1D).Methods: Continuous glucose monitoring, using CGMS system, was performed in 130 T1D patients with diabetes duration of 17....

Background and objectives: Evaluate the impact of therapy with GLP-1 analogues (liraglutide) on glycemic control and weight in patients with type 2 diabetes and poor metabolic control.Material and methods: We conducted a retrospective observational study analyzing 67 patients with type 2 diabetes mellitus and BMI >30 kg/m2, over 6 months of treatment. We evaluated HbA1c and weight at 3 and 6 months, performing statistical analysis with SPS...

Introduction: Several studies suggest DHEA and DHEAS (DHEA(S)) are related to memory enhancement and a better performance under stress. An anti-cortisol action may contribute to those relations. We looked for a new level of evidence, by studying DHEA(S) and cortisol relations to working memory (WM) and distraction in humans also at the electrophysiological level.Subjects and methods: Twenty-eight healthy female volunteers (18–26 years old) were pres...

Introduction: Several studies reported DHEA relations to memory and cognition improvement. An anti-cortisol action may contribute to those relations. The effect of working memory (WM) on DHEA levels is unknown. We studied DHEA and cortisol reactivity in humans after a WM stimulus with simultaneous distraction.Subjects and methods: Twenty eight healthy female volunteers (18–26 years old) were presented a well-established auditory-visual distraction t...

Introduction: The final height of children with congenital adrenal hyperplasia (CAH) seems to be compromised. That can happen because of the disease itself or because an excessive dose of corticoids used during treatment. This work evaluates the final stature SDS of a group of patients with CAH and correlates it with 17-hydroxyprogesterone levels (17OHP) and corticoid dose at 10 years of age and at puberty onset.Methods: Selection of children with CAH di...

Introduction: Medullary thyroid carcinoma (MTC) is a rare form of thyroid cancer, making up about 3–5% of all cases. It is characterized by the synthesis and secretion of calcitonin (Ct). Measurement of Ct has low specificity but is a highly sensitive method for the detection of MTC. MTC with normal or only slightly elevated Ct is a rare occurrence and there are few such reports in the literature.Case report: A 61-year-old male patient was referred ...